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01Markers · B vitamins

Vitamin B12

Cobalamin, a vitamin needed for nerve function, DNA and red blood cell production. The blood test measures total B12, most of it bound to carrier proteins.

Measured in
Blood (serum)
Units
pg/mL, pmol/L
Also called
cobalamin, cyanocobalamin, methylcobalamin
  1. Iron
  2. Creatine
  3. L-carnitine
  4. Vitamin D3
  5. Omega-3
  6. Ashwagandha
  7. Berberine
  8. Collagen
  9. Finnish sauna
  10. HIIT
  11. L-theanine
  12. Lion's mane
  13. Magnesium
  14. Melatonin
  15. Milk thistle
  16. NAC
  17. NAD+
  18. PQQ
  19. Red yeast rice
  20. Resveratrol
  21. Taurine
  22. Ubiquinol (CoQ10)
  23. Vitamin C
  24. Vitamin E
  25. Vitamin K2
  26. Zinc
  27. Zone 2 cardio
Vitamin B12 across the 27 supplements and practices researched so far · best evidence first

AWhat moves Vitamin B12

5 of 27 studied

In human studies, none of the 27 supplements and practices researched so far changed vitamin B12. 5 showed no change. 22 were never studied for it.
  • Supported 0
  • No effect 5
  • Conflicting 0
  • Not studied 22
See Vitamin B12 on the evidence map →Check claims about Vitamin B12 →

Studied, no change5

Studies looked and found no meaningful change. That is a result, not missing data.

IronNo changeGrade A

Studies of Iron found no change in vitamin B12.

Meta-analysis or review · 2 studies linked

Studied in: General

Iron supplementation does not affect B12 status. B12 deficiency may co-exist with IDA and must be assessed independently.

Open the Iron page →Check a claim about this →
CreatineNo changeGrade B

Studies of Creatine found no change in vitamin B12.

Human trials · 1 study linked

9 studies mention B12. No creatine-specific B12 endpoint. Vegetarian creatine users may have concurrent B12 deficiency — relevant for combined supplementation counseling but not a pharmacological interaction.

Open the Creatine page →Check a claim about this →
L-carnitineNo changeGrade B

Studies of L-carnitine found no change in vitamin B12.

Meta-analysis or review · 1 study linked

13 studies; no direct carnitine-B12 interaction mechanism.

Open the L-carnitine page →Check a claim about this →
Vitamin D3No changeGrade C

Studies of Vitamin D3 found no change in vitamin B12.

Human trials · Negligible effect · 1 study linked

Open the Vitamin D3 page →Check a claim about this →
Omega-3No changeGrade D

Studies of Omega-3 found no change in vitamin B12.

Small effect · 0 studies linked

This result is graded, but no study is linked to it yet. Treat it as unconfirmed.

Studied in: Adult, General

Open the Omega-3 page →Check a claim about this →

Not studied22

No usable human study has measured Vitamin B12 with these. A gap is not a negative result: nobody has looked.

AshwagandhaBerberineCollagenFinnish saunaHIITL-theanineLion's maneMagnesiumMelatoninMilk thistleNACNAD+PQQRed yeast riceResveratrolTaurineUbiquinol (CoQ10)Vitamin CVitamin EVitamin K2ZincZone 2 cardio

Commission research on a gap →

Why trials measure it. Trials report it to confirm B12 absorption and to study deficiency, often together with MMA.

About this marker: Vitamin B12 level (MedlinePlus, U.S. National Library of Medicine).

Evidence states come from published human studies found in PubMed and OpenAlex and read by a model pipeline. "Not studied" means no usable human study was found for this marker, which is a gap, not a negative result. Every result links its studies so you can check it.

Research summary for education. Not medical advice.