01Markers · B vitamins
Folate
Vitamin B9, needed to make DNA and red blood cells. Serum folate reflects recent intake; red-cell folate reflects the past few months.
- Measured in
- Blood (serum or red cells)
- Units
- ng/mL, nmol/L
- Also called
- folic acid, vitamin B9, RBC folate
- Vitamin C
- Resveratrol
- Iron
- Zinc
- Omega-3
- Magnesium
- Ashwagandha
- Berberine
- Collagen
- Creatine
- Finnish sauna
- HIIT
- L-carnitine
- L-theanine
- Lion's mane
- Melatonin
- Milk thistle
- NAC
- NAD+
- PQQ
- Red yeast rice
- Taurine
- Ubiquinol (CoQ10)
- Vitamin D3
- Vitamin E
- Vitamin K2
- Zone 2 cardio
AWhat moves Folate
6 of 27 studied
Moves it2
Human studies found a change. The grade reflects the studies behind it, from A (strongest) to D.
Vitamin CRaisesGrade B
Vitamin C raises folate.
Human trials · 1 study linked
58 studies. No intervention data showing vitamin C supplementation effect on serum folate levels.
ResveratrolLowersGrade C
Resveratrol lowers folate.
Human trials · 3 studies linked
12 corpus studies. No extracted RCT endpoint data for resveratrol effect on folate levels.
- Oral delivery of folate-targeted resveratrol-loaded nanoparticles for inflammatory bowel disease therapy in rats. (2020)
- Resveratrol-loaded folate targeted lipoprotein-mimetic nanoparticles with improved cytotoxicity, antioxidant activity and pharmacokinetic profile. (2020)
- Resveratrol loaded functionalized nanostructured lipid carriers for breast cancer targeting: Systematic development, characterization and pharmacokinetic evaluation. (2019)
Studied, no change4
Studies looked and found no meaningful change. That is a result, not missing data.
IronNo changeGrade A
Studies of Iron found no change in folate.
Meta-analysis or review · 11 studies linked
Iron supplementation does not directly affect serum folate. Co-supplementation with folate (IFA) is standard in pregnancy but folate effect is from the folate component, not iron.
- Oral iron supplements for children in malaria-endemic areas. (2026)
- Effectiveness of Health Education Interventions in Enhancing Iron-Folic Acid Supplement Utilization Among Pregnant Women: Systematic Review and Meta-analysis. (2025)
- Iron Deficiency Drives Th2-Mediated Immunity in Pediatric Atopic Dermatitis Through DNA Hypermethylation and TIGIT Suppression in IL-10-Producing Breg Cells. (2025)
- Global prevalences of erythropoiesis-associated micronutrient deficiencies (iron, folate, and vitamin B <sub>12</sub> ) among pregnant women: a systematic review and meta-analysis (2025)
- Interpersonal Communication Strategies to Increase Iron-Folic Acid Supplement Consumption: Reduction in Anemia Through Normative Innovations (RANI) Project. (2024)
- The prevalence and risk factors associated with Iron, vitamin B12 and folate deficiencies in pregnant women: A cross-sectional study in Mbeya, Tanzania (2023)
- +5 more studies
ZincNo changeGrade A
Studies of Zinc found no change in folate.
Meta-analysis or review · 4 studies linked
Large corpus count (102) reflects co-administration studies (zinc+folate). Zinc alone does not reliably alter serum folate. Complex absorption interactions exist but clinically not significant at standard doses.
- Zinc/carbon nanomaterials inhibit antibiotic resistance genes by affecting quorum sensing and microbial community in cattle manure production. (2023)
- Influencing factors of neural tube malformation: a systematic review and meta-analysis. (2025)
- The Efficacy of Zinc Supplementation Alone or in Combination for Improving Pregnancy and Infant Outcomes: A Systematic Review and Meta-Analysis. (2025)
- The Effect of Folate and Folate Plus Zinc Supplementation on Endocrine Parameters and Sperm Characteristics in Sub-Fertile Men: A Systematic Review and Meta-Analysis. (2017)
Omega-3No changeGrade B
Studies of Omega-3 found no change in folate.
Human trials · Negligible effect · 2 studies linked
18 studies in corpus but no direct supplementation effect on folate levels expected.
- Effects of Folic Acid Combined with DHA Supplementation on Cognitive Function and Amyloid-β-Related Biomarkers in Older Adults with Mild Cognitive Impairment by a Randomized, Double Blind, Placebo-Con (2021)
- Evidence for a protective (synergistic?) effect of B-vitamins and omega-3 fatty acids on cardiovascular diseases. (2004)
MagnesiumNo changeGrade D
Studies of Magnesium found no change in folate.
0 studies linked
This result is graded, but no study is linked to it yet. Treat it as unconfirmed.
Mg does not affect folate levels directly. Folate and Mg are co-factors in methylation cycle but Mg supplementation does not raise folate.
Not studied21
No usable human study has measured Folate with these. A gap is not a negative result: nobody has looked.
AshwagandhaBerberineCollagenCreatineFinnish saunaHIITL-carnitineL-theanineLion's maneMelatoninMilk thistleNACNAD+PQQRed yeast riceTaurineUbiquinol (CoQ10)Vitamin D3Vitamin EVitamin K2Zone 2 cardio