F2-isoprostanes

Meta-analysis or review · Small effect · 6 studies linked

Studied in: Adults, Oxidative stress conditions

13 corpus studies. Lipid peroxidation marker. Limited RCT data shows trend toward reduction consistent with antioxidant mechanism.

• '140R' Rootstock Regulates Resveratrol Content in 'Cabernet Sauvignon' Grapevine Leaves Through miRNA. (2024)
• Resveratrol supplementation improves functional performance in knee osteoarthritis by upregulating sirtuin 1: a randomized study. (2025)
• Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes. (2023)
• An open-label trial in Friedreich ataxia suggests clinical benefit with high-dose resveratrol, without effect on frataxin levels. (2015)
• Effects of chronic resveratrol supplementation in military firefighters undergo a physical fitness test--a placebo-controlled, double blind study. (2015)
• Effect of resveratrol and quercetin supplementation on redox status and inflammation after exercise (2013)

Meta-analysis or review · Small effect · 4 studies linked

Studied in: General adult, Smokers, Oxidative stress

Consistent with broader antioxidant effect (MDA↓, GSH↑, SOD↑). 32 studies in corpus. Effect inconsistent across individual trials.

• The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. (2024)
• Dietary omega-3 fatty acid supplementation does not impair vitamin E status or promote lipid peroxidation in growing horses. (2021)
• Effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic: a randomized clinical trial. (2018)
• Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega-3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial. (2015)

Moderate effect · 1 study linked

Studied in: NAFLD, Adult, Mixed sex

F2-isoprostanes considered most reliable in vivo oxidative stress marker; corroborates MDA findings

• Pervez MA, Khan DA, Ijaz A, Khan S et al. (2018)

7 studies linked

Studied in: Adults, Mixed populations, Elevated oxidative stress

• A High Vitamin C Micronutrient Supplement Is Unable to Attenuate Inflammation in People with Metabolic Syndrome but May Improve Metabolic Health Indices: A Randomised Controlled Trial. (2024)
• Inter-individual variability in redox and performance responses after antioxidant supplementation: A randomized double blind crossover study. (2023)
• Critically ill septic patients have elevated oxidative stress biomarkers: lack of attenuation by parenteral vitamin C. (2022)
• Vitamin C supplementation improves blood pressure and oxidative stress after acute exercise in patients with poorly controlled type 2 diabetes mellitus: A randomized, placebo-controlled, cross-over st (2021)
• Antioxidant supplementation, redox deficiencies and exercise performance: A falsification design (2020)
• Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial. (2019)
• +1 more studies

Human trials · 6 studies linked

Studied in: Cardiovascular, Metabolic syndrome

• The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials (2019)
• Short‐term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial (2016)
• Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: A randomized controlled trial (2011)
• Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes (2003)
• Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes (2002)
• Does high-dose coenzyme Q10 improve oxidative damage and clinical outcomes in Parkinson's disease? (2014)

Human trials · Moderate effect · 4 studies linked

Studied in: Smokers, Metabolic syndrome, Cardiac surgery, Adult

• Randomized controlled trial of (2020)
• Oxidative stress reduction related to the efficacy of n-3 polyunsaturated fatty acids in first episode schizophrenia: Secondary outcome analysis of the OFFER randomized trial (2017)
• Hanafy DA, Said GM, El-Feky ME, Kamal AM (2024)
• PubMed 23036088

Human trials · Small effect · 3 studies linked

Studied in: Adults, Oxidative stress conditions

19 studies reference F2-isoprostanes. Lipid peroxidation marker similar to MDA. Directionally consistent but less studied than MDA.

• Melatonin in Newborn Infants Undergoing Surgery: A Pilot Study on Its Effects on Postoperative Oxidative Stress (2023)
• Antioxidant Effect of Melatonin in Preterm Newborns. (2021)
• Dentin bonding agents and camphorquinone-induced cytotoxicity, 8-isoprostane and prostaglandin production is associated with CYP450, NQO1, NQO2, GST, and GSH peroxidase in human dental pulp cells. (2026)

Human trials · 3 studies linked

Studied in: Adults, T2D, Metabolic syndrome

F2-isoprostanes are arachidonic acid oxidation products (lipid peroxidation marker, similar to MDA). Zinc's NRF2 activation, SOD1 cofactor role, and metallothionein induction predict reduction consistent with robust MDA evidence. Dedicated F2-isoprostane RCT data sparse but directionally supported.

• Clinical efficacy of zinc supplementation in improving antioxidant defense system: A comprehensive systematic review and time-response meta-analysis of controlled clinical trials. (2021)
• Clinical effectiveness of zinc supplementation on the biomarkers of oxidative stress: A systematic review and meta-analysis of randomized controlled trials. (2020)
• High 15-F2t-Isoprostane Levels in Patients with a Previous History of Nonmelanoma Skin Cancer: The Effects of Supplementary Antioxidant Therapy. (2015)

Human trials · Modest effect · 2 studies linked

Studied in: General adult

9 studies; F2-isoprostanes reflect arachidonic acid oxidation. Reduction consistent with membrane lipid peroxidation protection.

• Oxidative stress in response to forearm ischemia-reperfusion with and without carnitine administration. (2010)
• Reduction of butyrylcholinesterase activity in plasma from patients with disorders of propionate metabolism is prevented by treatment with L-carnitine and protein restriction. (2012)

Human trials · Small effect · 1 study linked

Studied in: Iv iron recipients

F2-isoprostanes (lipid peroxidation marker) transiently elevated post-IV iron infusion. Modern low-labile-iron formulations (FCM, ferric derisomaltose) produce less oxidative stress than first-generation iron dextran.

• Analysis of oxidative stress, inflammation and endothelial function following intravenous iron in chronic kidney disease in the Iron and Heart Trial. (2022)

Human trials · Small effect · 1 study linked

Studied in: T2DM, MetS

3 studies in corpus. Limited RCT data suggesting F2-isoprostane reduction in metabolic populations. Consistent with GSH/Nrf2 mechanism.

• Effects of Potassium Magnesium Citrate Supplementation on 24-Hour Ambulatory Blood Pressure and Oxidative Stress Marker in Prehypertensive and Hypertensive Subjects. (2016)

Human trials · 1 study linked

3 corpus studies — priority extraction target for oxidative stress assessment.

• Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study. (2020)

Human trials · 1 study linked

Studied in: No human data

• Consumption of Sylimarin, Pyrroloquinoline Quinone Sodium Salt and Myricetin: Effects on Alcohol Levels and Markers of Oxidative Stress-A Pilot Study. (2024)

1 study linked

Studied in: Healthy volunteers

Non-significant trend only; underpowered sub-study within PK trial; no dedicated placebo arm for this endpoint; directionally consistent with antioxidant mechanism but insufficient to support efficacy claim; Grade D

• The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. (2013)

Human trials · 3 studies linked

5 studies in corpus mention F2-isoprostanes but no creatine-specific endpoint extraction. Indirect antioxidant effect plausible but unmeasured.

• Conjugated linoleic acid combined with creatine monohydrate and whey protein supplementation during strength training. (2009)
• Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders. (2007)
• Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men. (2003)