8-OHdG

Moderate effect · 4 studies linked

Studied in: Adult, Oxidative stress, NAFLD

8-OHdG (8-hydroxy-2'-deoxyguanosine) is a DNA oxidative damage marker. VE supplementation reduces 8-OHdG in oxidative-stress-driven conditions, consistent with lipid peroxidation chain-breaking mechanism. 17 studies in corpus.

• Antioxidant activity of Hydroxytyrosol and Vitamin E reduces systemic inflammation in children with paediatric NAFLD. (2021)
• Tocotrienol supplementation suppressed bone resorption and oxidative stress in postmenopausal osteopenic women: a 12-week randomized double-blinded placebo-controlled trial (2018)
• α-Tocopherol supplementation reduces biomarkers of oxidative stress in children with Down syndrome: a randomized controlled trial. (2014)
• The effect of antioxidant vitamins E and C on cognitive performance of the elderly with mild cognitive impairment in Isfahan, Iran: a double-blind, randomized, placebo-controlled trial. (2014)

Human trials · Small effect · 2 studies linked

Studied in: Athletes, Healthy adults

8-hydroxy-2-deoxyguanosine (oxidative DNA damage marker) reduced in some exercise-context studies following creatine supplementation; consistent with proposed cytoprotective and mitochondrial stabilization mechanisms; insufficient dedicated RCT evidence for grade B

• The role of resistance training and creatine supplementation on oxidative stress, antioxidant defense, muscle strength, and quality of life in older adults. (2023)
• Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men. (2003)

Human trials · 2 studies linked

Studied in: Multiple sclerosis, European

• Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial (2014)
• Short‐term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial (2016)

Human trials · Small effect · 1 study linked

Studied in: Iron overload, Iv iron recipients

8-OHdG (DNA oxidative damage marker) may transiently increase with IV iron via Fenton-generated hydroxyl radicals. Clinically relevant only in iron overload or high-dose IV iron; not observed at oral therapeutic doses.

• Alpha-lipoic acid improved anemia, erythropoietin resistance, maintained glycemic control, and reduced cardiovascular risk in diabetic patients on hemodialysis: a multi-center prospective randomized c (2022)

Human trials · Moderate effect · 1 study linked

Studied in: Renal failure, Oncology, Adult

• Mahmoudinezhad M et al. (2023)

Small effect · 1 study linked

Studied in: Adult, Oxidative stress, Metabolic syndrome

8-OHdG (oxidative DNA damage marker) reduced alongside MDA in oxidative stress MAs; effect consistent with broader antioxidant enzyme upregulation.

• Saboori S, Shab-Bidar S, Speakman JR, Yousefi Rad E, Djafarian K (2020)

Human trials · 1 study linked

Studied in: Moderate hypercholesterolemia, Adult

• A red yeast rice-olive extract supplement reduces biomarkers of oxidative stress, OxLDL and Lp-PLA (2017)

Small to moderate effect · 0 studies linked

This result is graded, but no study is linked to it yet. Treat it as unconfirmed.

Studied in: Adults, Metabolic syndrome, Oxidative stress conditions

DNA oxidative damage marker; 29 studies in corpus. Reduction consistent with ROS scavenging mechanism. Limited MA-level data but directionally consistent with MDA reduction.

Human trials · Modest effect · 1 study linked

Studied in: CKD, General adult

8 studies; 8-OHdG is a DNA oxidation marker. Reduction consistent with antioxidant mechanism (mech_004). Limited human RCT data as primary endpoint.

• DNA damage induced by alloisoleucine and other metabolites in maple syrup urine disease and protective effect of l-carnitine. (2019)

Small effect · 1 study linked

Studied in: T2DM

8-Hydroxy-2'-deoxyguanosine (DNA oxidation marker) reduced in T2DM RCTs; insufficient trials for grade A.

• Veronese N, Pizzol D, Demurtas J, et al. (2022)

Human trials · Small effect · 1 study linked

Studied in: T2DM, Metabolic syndrome, Adults

22 corpus studies. Oxidative DNA damage marker. Some RCTs report reduction consistent with Nrf2/antioxidant mechanism. Limited MA-level pooling.

• Resveratrol ameliorates the oxidative damage induced by arsenic trioxide in the feline lung. (2013)

Human trials · 1 study linked

Studied in: Adults, Elevated oxidative stress

17 studies. DNA oxidation marker. Some small RCTs show reduction in urinary 8-OHdG with vitamin C supplementation but data thin and heterogeneous.

• Ameliorative effects of Sida acuta and vitamin C on serum DNA damage, pro-inflammatory and anti-inflammatory cytokines in roosters fed aflatoxin B (2023)

Human trials · 1 study linked

Studied in: T2D, Adults

Only a few small studies. Direction consistent with MDA reduction and antioxidant enzyme data but insufficient RCT evidence for Grade B. Mechanistic plausibility high via zinc finger DNA repair proteins and ROS reduction.

• Relationship Between Zinc Status and DNA Oxidative Damage in Patients with Type 2 Diabetes Mellitus. (2021)

Small effect · 0 studies linked

This result is graded, but no study is linked to it yet. Treat it as unconfirmed.

Studied in: Animal models, DILI, Oxidative stress conditions

6 studies; predominantly animal model data. Directional decrease consistent with antioxidant mechanism (mech_001, mech_004). No adequately powered human RCT with 8-OHdG as primary endpoint.

Lab or animal studies · 0 studies linked

This result is graded, but no study is linked to it yet. Treat it as unconfirmed.

Studied in: Preclinical

Lab or animal studies · 0 studies linked

This result is graded, but no study is linked to it yet. Treat it as unconfirmed.

Studied in: General

6 corpus studies.

Meta-analysis or review · 1 study linked

Studied in: Healthy adults, Athletes

• Intracellular Oxidative Stress Induced by Physical Exercise in Adults: Systematic Review and Meta-Analysis. (2022)