01Markers · Hormones
Estradiol
The main form of estrogen before menopause, made mostly by the ovaries and in smaller amounts by fat tissue and the testes.
- Measured in
- Blood (serum)
- Units
- pg/mL, pmol/L
- Also called
- E2, estrogen
- Melatonin
- L-carnitine
- Ashwagandha
- Zinc
- NAC
- Milk thistle
- Omega-3
- HIIT
- Resveratrol
- Berberine
- Collagen
- Creatine
- Finnish sauna
- Iron
- L-theanine
- Lion's mane
- Magnesium
- NAD+
- PQQ
- Red yeast rice
- Taurine
- Ubiquinol (CoQ10)
- Vitamin C
- Vitamin D3
- Vitamin E
- Vitamin K2
- Zone 2 cardio
AWhat moves Estradiol
10 of 27 studied
Moves it5
Human studies found a change. The grade reflects the studies behind it, from A (strongest) to D.
MelatoninRaisesGrade A
Melatonin raises estradiol.
Meta-analysis or review · 5 studies linked
189 studies reference estradiol. Aromatase modulation mechanism (mech_mel_008) is theoretical. ART context shows possible modulation but no systematic MA for serum estradiol.
- Impact of melatonin administration on sperm quality, steroid hormone levels, and testicular blood flow parameters in small ruminants: A meta-analysis. (2024)
- Low-Dose Melatonin, Climacteric Symptoms and Sleep in Female Shift Workers: A Randomized Controlled Trial. (2026)
- Melatonin as a therapeutic agent for alleviating endothelial dysfunction in cardiovascular diseases: Emphasis on oxidative stress. (2023)
- Administration of melatonin improves testicular blood flow, circulating hormones, and semen quality in Shiba goats. (2020)
- Effects of exogenous melatonin on sleep quality and menopausal symptoms in menopausal women: a systematic review and meta-analysis of randomized controlled trials. (2021)
L-carnitineRaisesGrade B
L-carnitine raises estradiol.
Human trials · 3 studies linked
15 studies; some PCOS trials report estradiol but direction not consistently extractable.
- The effect of adding L-Carnitine to the GnRH-antagonist protocol on assisted reproductive technology outcome in women with polycystic ovarian syndrome: a randomized clinical trial. (2023)
- Adding L-carnitine to clomiphene resistant PCOS women improves the quality of ovulation and the pregnancy rate. A randomized clinical trial. (2014)
- Effects of L-carnitine supplementation in pregnant sows on plasma concentrations of insulin-like growth factors, various hormones and metabolites and chorion characteristics. (2006)
AshwagandhaRaisesGrade B
Ashwagandha raises estradiol.
Human trials · 2 studies linked
- Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. (2021)
- A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males. (2019)
ZincLowersGrade C
Zinc lowers estradiol.
Human trials · 2 studies linked
Zinc inhibits aromatase, reducing testosterone-to-estradiol conversion. Effect population-specific: relevant in males with documented hyperestrogenemia or PCOS females. te_2023 systematic review confirms zinc-estrogen interaction. Limited RCT data as primary endpoint.
NACLowersGrade C
NAC lowers estradiol.
Human trials · Small effect · 0 studies linked
This result is graded, but no study is linked to it yet. Treat it as unconfirmed.
Studied, no change2
Studies looked and found no meaningful change. That is a result, not missing data.
Milk thistleNo changeGrade B
Studies of Milk thistle found no change in estradiol.
Human trials · 1 study linked
8 studies mention estradiol; predominantly in vitro ERβ binding studies. No human hormonal endpoint data.
Omega-3No changeGrade C
Studies of Omega-3 found no change in estradiol.
Small effect · 0 studies linked
This result is graded, but no study is linked to it yet. Treat it as unconfirmed.
Limited direct evidence; some mechanistic data suggesting modest estrogenic modulation at high DHA doses — no consistent MA signal.
Mixed results3
Studies disagree, or the direction depends on who was studied.
HIITMixed resultsGrade B
Studies of HIIT and estradiol disagree.
Human trials · 2 studies linked
- Impact of Probiotic Supplementation and High-Intensity Interval Training on Primary Dysmenorrhea: A Double-Blind, Randomized Controlled Trial Investigating Inflammation and Hormonal Modulation (2025)
- High-intensity Interval Training and Mindfulness Breathing Induce Hormonal, Metabolic, and Anticarcinogenic Effects in Obese Postmenopausal Women: A Randomized Controlled Trial (2025)
ResveratrolMixed resultsGrade C
Studies of Resveratrol and estradiol disagree.
Human trials · 2 studies linked
89 corpus studies. PCOS and postmenopausal MAs exist but dedicated estradiol-endpoint analysis sparse.
- A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones. (2014)
- Steroidogenic activity of liposomal methylated resveratrol analog 3,4,5,4'-tetramethoxystilbene (DMU-212) in human luteinized granulosa cells in a primary three-dimensional in vitro model. (2023)
BerberineMixed resultsGrade D
Studies of Berberine and estradiol disagree.
0 studies linked
This result is graded, but no study is linked to it yet. Treat it as unconfirmed.
Not studied17
No usable human study has measured Estradiol with these. A gap is not a negative result: nobody has looked.
CollagenCreatineFinnish saunaIronL-theanineLion's maneMagnesiumNAD+PQQRed yeast riceTaurineUbiquinol (CoQ10)Vitamin CVitamin D3Vitamin EVitamin K2Zone 2 cardio