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01Markers · Liver

ALP

Alkaline phosphatase

An enzyme found mainly in the liver and bones. Blood levels rise with bile duct blockage and with bone growth or turnover.

Measured in
Blood (serum)
Units
U/L
Also called
ALK PHOS, ALKP
  1. Vitamin D3
  2. Vitamin E
  3. Resveratrol
  4. L-carnitine
  5. Melatonin
  6. L-theanine
  7. Taurine
  8. Ubiquinol (CoQ10)
  9. NAC
  10. Berberine
  11. Collagen
  12. Milk thistle
  13. Omega-3
  14. Creatine
  15. Vitamin C
  16. HIIT
  17. Zinc
  18. Iron
  19. Ashwagandha
  20. Vitamin K2
  21. Lion's mane
  22. Finnish sauna
  23. Magnesium
  24. NAD+
  25. PQQ
  26. Red yeast rice
  27. Zone 2 cardio
ALP across the 27 supplements and practices researched so far · best evidence first

AWhat moves ALP

21 of 27 studied

In human studies, 10 of the 27 supplements and practices researched so far lowered ALP. 9 showed no change and 2 had mixed results. 6 were never studied for it.
  • Supported 10
  • No effect 9
  • Conflicting 2
  • Not studied 6
See ALP on the evidence map →Check claims about ALP →

Moves it10

Human studies found a change. The grade reflects the studies behind it, from A (strongest) to D.

Vitamin D3LowersGrade A

Vitamin D3 lowers ALP.

Meta-analysis or review · Small effect · 33 studies linked

Studied in: Deficient baseline, CKD, Elderly

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Vitamin ELowersGrade A

Vitamin E lowers ALP.

Human trials · Small effect · 29 studies linked

Studied in: NASH, Nondiabetic, Hp2-2, Adults

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ResveratrolLowersGrade A

Resveratrol lowers ALP.

Meta-analysis or review · 23 studies linked

Studied in: Adults

102 corpus studies mention ALP but no extracted RCT outcome data in current scaffold. Likely assessed as safety parameter in hepatic trials; requires extraction from existing study stubs.

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L-carnitineLowersGrade A

L-carnitine lowers ALP.

Meta-analysis or review · 18 studies linked

Studied in: General adult

36 studies in corpus mention ALP but dedicated effect extraction not completed. ALP elevation is more indicative of cholestatic than hepatocellular pathology; L-carnitine's hepatoprotective mechanism (CPT-I, steatosis reduction) would primarily affect hepatocellular markers.

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MelatoninLowersGrade A

Melatonin lowers ALP.

Meta-analysis or review · 9 studies linked

121 studies reference ALP in corpus but no MA-level data extracted for melatonin's direct effect on ALP. Insufficient evidence to characterize direction.

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L-theanineLowersGrade B

L-theanine lowers ALP.

Human trials · 11 studies linked

Studied in: No human data

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TaurineLowersGrade B

Taurine lowers ALP.

Human trials · 5 studies linked

Studied in: General

40 corpus studies but no extracted human effect data. Likely hepatoprotective context — bile acid metabolism pathway.

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Ubiquinol (CoQ10)LowersGrade B

Ubiquinol (CoQ10) lowers ALP.

Human trials · 5 studies linked

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NACLowersGrade B

NAC lowers ALP.

Human trials · Small effect · 3 studies linked

Studied in: Liver disease, Adult

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BerberineLowersGrade B

Berberine lowers ALP.

Human trials · 1 study linked

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Studied, no change9

Studies looked and found no meaningful change. That is a result, not missing data.

CollagenNo changeGrade A

Studies of Collagen found no change in ALP.

Meta-analysis or review · 30 studies linked

Studied in: Postmenopausal women

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Milk thistleNo changeGrade A

Studies of Milk thistle found no change in ALP.

Meta-analysis or review · 19 studies linked

Studied in: NAFLD, Cholestatic liver disease, HCV, Primary biliary cholangitis

71 studies in corpus. ALP less consistently reduced; most pronounced effect in cholestatic etiologies. In NAFLD with elevated ALP, reduction correlates with steatosis improvement. Some trials show no significant ALP effect when baseline ALP is within normal range.

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Omega-3No changeGrade A

Studies of Omega-3 found no change in ALP.

Meta-analysis or review · Small effect · 19 studies linked

Studied in: Adult, NAFLD

WMD −2.1 IU/L (95% CI −6.8 to +2.6, p=0.38). Non-significant reduction in NAFLD populations.

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CreatineNo changeGrade A

Studies of Creatine found no change in ALP.

12 studies linked

Studied in: Female, General adult

ALP is present in liver, bone, kidney, and intestine. No creatine-attributable elevation in female safety MA.

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Vitamin CNo changeGrade A

Studies of Vitamin C found no change in ALP.

Meta-analysis or review · 10 studies linked

106 studies mention ALP, many in bone/mineral metabolism context rather than hepatic. No vitamin C → ALP RCT data extracted.

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HIITNo changeGrade A

Studies of HIIT found no change in ALP.

Meta-analysis or review · 6 studies linked

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ZincNo changeGrade B

Studies of Zinc found no change in ALP.

Human trials · 16 studies linked

Studied in: CKD, Hemodialysis, Zinc deficient children, Adults

ALP is a zinc-metalloenzyme; deficiency impairs activity. High corpus study count (179) reflects broad disease context including bone, liver, and pediatric studies. Direct supplementation RCT evidence for ALP as primary endpoint is limited and heterogeneous.

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IronNo changeGrade B

Studies of Iron found no change in ALP.

Human trials · 10 studies linked

Studied in: General

No consistent iron supplementation effect on ALP. Ferric carboxymaltose-induced hypophosphatemia (via FGF23) may indirectly stimulate bone ALP as a compensatory response, but direct supplementation effect is not established.

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AshwagandhaNo changeGrade B

Studies of Ashwagandha found no change in ALP.

Human trials · 2 studies linked

Studied in: Healthy adults standard doses

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Mixed results2

Studies disagree, or the direction depends on who was studied.

Vitamin K2Mixed resultsGrade A

Studies of Vitamin K2 and ALP disagree.

Meta-analysis or review · Small effect · 5 studies linked

Studied in: Postmenopausal women, Japanese, Osteoporosis

36 studies reference ALP; however, ALP in K2 literature predominantly reflects bone-specific ALP (BSAP), not hepatic ALP. Increases reflect enhanced osteoblast activity (formation marker), not hepatic injury. Total ALP direction depends on population context (bone vs liver disease).

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Lion's maneMixed resultsGrade C

Studies of Lion's mane and ALP disagree.

Human trials · 1 study linked

Studied in: Healthy volunteers, Asian, Short term, Pilot

Xiao-qian 2021 measured serum biochemical markers including liver enzymes; direction and magnitude not confirmable from abstract only. Insufficient to assign direction.

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Not studied6

No usable human study has measured ALP with these. A gap is not a negative result: nobody has looked.

Finnish saunaMagnesiumNAD+PQQRed yeast riceZone 2 cardio

Commission research on a gap →

Why trials measure it. Reported in liver panels and in bone studies, where it tracks bone formation.

About this marker: Alkaline Phosphatase (MedlinePlus, U.S. National Library of Medicine).

Evidence states come from published human studies found in PubMed and OpenAlex and read by a model pipeline. "Not studied" means no usable human study was found for this marker, which is a gap, not a negative result. Every result links its studies so you can check it.

Research summary for education. Not medical advice.