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01Markers · Heart

Troponin

Cardiac troponin

A protein in heart muscle that enters the blood when heart muscle cells are injured. High-sensitivity tests detect very small amounts.

Measured in
Blood (serum or plasma)
Units
ng/L, ng/mL
Also called
troponin T, troponin I, hs-troponin
  1. Vitamin C
  2. Melatonin
  3. NAC
  4. L-carnitine
  5. Ubiquinol (CoQ10)
  6. Taurine
  7. Berberine
  8. Finnish sauna
  9. Resveratrol
  10. Creatine
  11. Vitamin D3
  12. HIIT
  13. Iron
  14. Omega-3
  15. Ashwagandha
  16. Collagen
  17. L-theanine
  18. Lion's mane
  19. Magnesium
  20. Milk thistle
  21. NAD+
  22. PQQ
  23. Red yeast rice
  24. Vitamin E
  25. Vitamin K2
  26. Zinc
  27. Zone 2 cardio
Troponin across the 27 supplements and practices researched so far · best evidence first

AWhat moves Troponin

14 of 27 studied

In human studies, 8 of the 27 supplements and practices researched so far lowered troponin and 1 raised it. 5 showed no change. 13 were never studied for it.
  • Supported 9
  • No effect 5
  • Conflicting 0
  • Not studied 13
See Troponin on the evidence map →Check claims about Troponin →

Moves it9

Human studies found a change. The grade reflects the studies behind it, from A (strongest) to D.

Vitamin CLowersGrade A

Vitamin C lowers troponin.

Meta-analysis or review · 5 studies linked

Studied in: Cardiac surgery patients, High dose iv, Clinical setting

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MelatoninLowersGrade A

Melatonin lowers troponin.

Meta-analysis or review · Small effect · 4 studies linked

Studied in: Adults, CABG, Cardiac surgery

CABG perioperative MA suggests troponin reduction; limited studies. Grade C.

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NACLowersGrade A

NAC lowers troponin.

Meta-analysis or review · Small effect · 4 studies linked

Studied in: Cardiac surgery, Adult

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L-carnitineLowersGrade B

L-carnitine lowers troponin.

Human trials · Modest effect · 6 studies linked

Studied in: Post MI, Cardiac surgery

12 studies; troponin reduction reported in post-MI and cardiac surgery contexts, consistent with cardioprotective mechanism. Reflects reduced myocardial injury.

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Ubiquinol (CoQ10)LowersGrade B

Ubiquinol (CoQ10) lowers troponin.

Human trials · 3 studies linked

Studied in: Cardiac surgery, Coronary artery bypass graft

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TaurineLowersGrade B

Taurine lowers troponin.

Human trials · 2 studies linked

Studied in: Cardiac surgery animal, Ischemia reperfusion

11 corpus studies.

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BerberineLowersGrade C

Berberine lowers troponin.

Human trials · 1 study linked

Studied in: Post cardiac surgery, Chinese

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Finnish saunaRaisesGrade C

Finnish sauna raises troponin.

Human trials · 1 study linked

Studied in: General adult, Cardiac patient

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ResveratrolLowersGrade C

Resveratrol lowers troponin.

Meta-analysis or review · 1 study linked

Studied in: Adults

13 corpus studies. Primarily in ischemia-reperfusion animal models. No clinical RCT troponin endpoint data extracted.

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Studied, no change5

Studies looked and found no meaningful change. That is a result, not missing data.

CreatineNo changeGrade A

Studies of Creatine found no change in troponin.

Meta-analysis or review · Negligible effect · 51 studies linked

Studied in: Heart failure patients, Myocardial infarction patients

horjus_2011 Cochrane SR (n=1474): No significant effect on cardiac troponin in heart failure/MI patients receiving creatine or phosphocreatine as add-on therapy. Corpus coverage: 130 studies. No troponin elevation in supplementation context confirms absence of cardiotoxicity.

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Vitamin D3No changeGrade B

Studies of Vitamin D3 found no change in troponin.

Human trials · 2 studies linked

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HIITNo changeGrade B

Studies of HIIT found no change in troponin.

Human trials · 1 study linked

Studied in: Cardiac patients, Healthy adults, Coronary artery disease

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IronNo changeGrade B

Studies of Iron found no change in troponin.

Human trials · 1 study linked

Studied in: Heart failure

IV iron in HF trials has not demonstrated troponin elevation (no myocardial injury signal). Troponin is a safety endpoint, not an efficacy marker for iron therapy.

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Omega-3No changeGrade C

Studies of Omega-3 found no change in troponin.

Small effect · 0 studies linked

This result is graded, but no study is linked to it yet. Treat it as unconfirmed.

Studied in: Adult, Cardiovascular

No consistent effect on baseline troponin. Post-ischaemic cardioprotection (reduced troponin release) seen in animal models and small RCTs only.

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Not studied13

No usable human study has measured Troponin with these. A gap is not a negative result: nobody has looked.

AshwagandhaCollagenL-theanineLion's maneMagnesiumMilk thistleNAD+PQQRed yeast riceVitamin EVitamin K2ZincZone 2 cardio

Commission research on a gap →

Why trials measure it. Trials report it as a measure of heart muscle injury, for example after surgery or extreme endurance exercise.

About this marker: Troponin Test (MedlinePlus, U.S. National Library of Medicine).

Evidence states come from published human studies found in PubMed and OpenAlex and read by a model pipeline. "Not studied" means no usable human study was found for this marker, which is a gap, not a negative result. Every result links its studies so you can check it.

Research summary for education. Not medical advice.