01Markers · Heart
NT-proBNP
N-terminal pro-B-type natriuretic peptide
A protein fragment released when heart muscle is stretched by extra pressure or volume. Levels are high in heart failure.
- Measured in
- Blood (plasma or serum)
- Units
- pg/mL, ng/L
- Also called
- BNP
- L-carnitine
- Iron
- Finnish sauna
- HIIT
- Ubiquinol (CoQ10)
- Melatonin
- NAC
- Omega-3
- Berberine
- Taurine
- Creatine
- Vitamin C
- Vitamin D3
- Ashwagandha
- Collagen
- L-theanine
- Lion's mane
- Magnesium
- Milk thistle
- NAD+
- PQQ
- Red yeast rice
- Resveratrol
- Vitamin E
- Vitamin K2
- Zinc
- Zone 2 cardio
AWhat moves NT-proBNP
13 of 27 studied
Moves it10
Human studies found a change. The grade reflects the studies behind it, from A (strongest) to D.
L-carnitineLowersGrade A
L-carnitine lowers NT-proBNP.
Meta-analysis or review · Modest effect · 8 studies linked
11 studies; NT-proBNP reduction reported in heart failure and dialysis contexts. Reflects improved cardiac function (LVEF improvement) rather than direct biomarker modulation.
- Efficacy of L-Carnitine for Dilated Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials. (2021)
- Effects of Reducing L-Carnitine Supplementation on Carnitine Kinetics and Cardiac Function in Hemodialysis Patients: A Multicenter, Single-Blind, Placebo-Controlled, Randomized Clinical Trial. (2021)
- Levocarnitine Improves Cardiac Function in Hemodialysis Patients With Left Ventricular Hypertrophy: A Randomized Controlled Trial. (2016)
- [Using L-carnitine to improve the adaptation of young athletes to physical load and the correction of stress-induced cardiomyopathy]. (2014)
- Heart dysfunction induced by choline-deficiency in adult rats: the protective role of L-carnitine. (2013)
- [Influence of levocarnitine on heart function and endocrine among patients with heart failure]. (2013)
- +2 more studies
IronLowersGrade A
Iron lowers NT-proBNP.
Meta-analysis or review · Moderate effect · 7 studies linked
NT-proBNP reduction not seen in all IV iron HF trials — IRONOUT-HF (oral iron) showed no NT-proBNP improvement, reinforcing route-dependent bioavailability
- Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: systematic review and meta-analysis of randomised clinical trials (2013)
- The correlation between cardiac T2*MRI and B-Type natriuretic peptides in patients with transfusion-dependent anemias and systemic iron overload: a systematic review and meta-analysis. (2026)
- Patient reported outcome measures and cardiovascular outcomes following high dose modern intravenous iron in non-dialysis dependent chronic kidney disease: secondary analysis of ExplorIRON-CKD (2023)
- IV Sodium Ferric Gluconate Complex in Patients With Iron Deficiency Hospitalized due to Acute Heart Failure-Investigator Initiated, Randomized Controlled Trial. (2022)
- Supplementation with Iron in Pulmonary Arterial Hypertension. Two Randomized Crossover Trials. (2021)
- Effects and Safety of Oral Iron for Heart Failure with Iron Deficiency: A Systematic Review and Meta-Analysis with Trial Sequential Analysis. (2022)
- +1 more studies
Finnish saunaLowersGrade B
Finnish sauna lowers NT-proBNP.
Meta-analysis or review · 7 studies linked
- Effects of sauna bath on heart failure: A systematic review and meta-analysis. (2018)
- Can heat therapy help patients with heart failure? (2020)
- Beneficial effects of Waon therapy on patients with chronic heart failure: results of a prospective multicenter study. (2008)
- Repeated sauna treatment improves vascular endothelial and cardiac function in patients with chronic heart failure (2002)
- Waon Therapy for Managing Chronic Heart Failure - Results From a Multicenter Prospective Randomized WAON-CHF Study. (2016)
- Effect of Waon Therapy in Individuals With Heart Failure: A Systematic Review (2018)
- +1 more studies
HIITLowersGrade B
HIIT lowers NT-proBNP.
Meta-analysis or review · 3 studies linked
- Meta-analysis of Exercise Training on Left Ventricular Ejection Fraction in Heart Failure with Reduced Ejection Fraction: A 10-year Update. (2019)
- Meta-analysis of aerobic interval training on exercise capacity and systolic function in patients with heart failure and reduced ejection fractions. (2013)
- The effects of high-intensity interval training and moderate-intensity continuous training on patients underwent Coronary Artery Bypass Graft surgery; a systematic review. (2024)
Ubiquinol (CoQ10)LowersGrade B
Ubiquinol (CoQ10) lowers NT-proBNP.
Human trials · 3 studies linked
- Ubiquinol Improves Endothelial Function in Patients with Heart Failure with Reduced Ejection Fraction: A Single-Center, Randomized Double-Blind Placebo-Controlled Crossover Pilot Study. (2020)
- Coenzyme Q10 in the Treatment of Heart Failure with Preserved Ejection Fraction: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial (2021)
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction. (2022)
MelatoninImprovesGrade B
Melatonin improves NT-proBNP.
Human trials · 1 study linked
6 studies reference NT-proBNP. No MA-level data. Heart failure adjunct MA exists (Qin 2025) but NT-proBNP as endpoint not extracted.
NACLowersGrade B
NAC lowers NT-proBNP.
Human trials · Small effect · 1 study linked
Omega-3LowersGrade B
Omega-3 lowers NT-proBNP.
Small effect · 0 studies linked
This result is graded, but no study is linked to it yet. Treat it as unconfirmed.
Reductions in NT-proBNP observed in heart failure and post-MI populations in multiple RCTs; evidence grade B pending dedicated MA.
BerberineLowersGrade C
Berberine lowers NT-proBNP.
Human trials · 3 studies linked
- Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. (2003)
- Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy. (2018)
- Development of Natural Polysaccharide-Based Nanoparticles of Berberine to Enhance Oral Bioavailability: Formulation, Optimization, Ex Vivo, and In Vivo Assessment. (2021)
TaurineLowersGrade D
Taurine lowers NT-proBNP.
Lab or animal studies · 0 studies linked
This result is graded, but no study is linked to it yet. Treat it as unconfirmed.
4 corpus studies. NT-proBNP would be expected to decrease if taurine improves cardiac function per Azuma CHF series.
Studied, no change3
Studies looked and found no meaningful change. That is a result, not missing data.
CreatineNo changeGrade B
Studies of Creatine found no change in NT-proBNP.
Human trials · 3 studies linked
NT-proBNP not significantly reduced in heart failure RCTs; cardiac energy substrate hypothesis (PCr as myocardial fuel during ischemia) not confirmed via NT-proBNP endpoint; limited trial data in HF population
- Trimetazidine in heart failure with preserved ejection fraction: a randomized controlled cross-over trial. (2023)
- Oxidative phosphorylation in creatine transporter deficiency. (2021)
- [Effects of phosphocreatine on plasma brain natriuretic peptide level in elderly patients with chronic congestive heart failure]. (2009)
Vitamin CNo changeGrade B
Studies of Vitamin C found no change in NT-proBNP.
Human trials · 1 study linked
1 study. Evidence gap.
Vitamin D3No changeGrade C
Studies of Vitamin D3 found no change in NT-proBNP.
Human trials · Negligible effect · 0 studies linked
This result is graded, but no study is linked to it yet. Treat it as unconfirmed.
Not studied14
No usable human study has measured NT-proBNP with these. A gap is not a negative result: nobody has looked.
AshwagandhaCollagenL-theanineLion's maneMagnesiumMilk thistleNAD+PQQRed yeast riceResveratrolVitamin EVitamin K2ZincZone 2 cardio