01Markers · Minerals
Phosphate
A charged form of phosphorus that works with calcium in bones and teeth and is used in energy metabolism. The kidneys control how much stays in the blood.
- Measured in
- Blood (serum)
- Units
- mg/dL, mmol/L
- Also called
- phosphorus, inorganic phosphate
- Iron
- Vitamin D3
- Creatine
- L-carnitine
- Berberine
- NAD+
- Magnesium
- Vitamin C
- Ashwagandha
- Ubiquinol (CoQ10)
- Zinc
- Omega-3
- Collagen
- Finnish sauna
- HIIT
- L-theanine
- Lion's mane
- Melatonin
- Milk thistle
- NAC
- PQQ
- Red yeast rice
- Resveratrol
- Taurine
- Vitamin E
- Vitamin K2
- Zone 2 cardio
AWhat moves Phosphate
12 of 27 studied
Moves it6
Human studies found a change. The grade reflects the studies behind it, from A (strongest) to D.
IronLowersGrade A
Iron lowers phosphate.
Meta-analysis or review · Moderate effect · 11 studies linked
FORMULATION-SPECIFIC: Ferric carboxymaltose (FCM) elevates intact FGF23, causing renal phosphate wasting. Hypophosphatemia (<2.0 mg/dL) occurs in 50–75% of FCM infusions. Ferric derisomaltose has significantly lower hypophosphatemia incidence. Oral iron and iron sucrose do not cause phosphate changes. Monitor serum ...
- Efficacy, Safety, and Tolerability of Ferric Carboxymaltose and Iron Sucrose in Iron-Deficiency Anemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (2025)
- Ferric Carboxymaltose (FCM)-Associated Hypophosphatemia (HPP): A Systematic Review. (2025)
- Characterization of serum phosphate levels over time with intravenous ferric carboxymaltose versus placebo as treatment for heart failure with reduced ejection fraction and iron deficiency: An explora (2025)
- Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial (2025)
- Mineral supplementation for very preterm infants fed fortified human milk. (2024)
- Intravenous Iron-Induced Hypophosphatemia: An Emerging Syndrome. (2021)
- +5 more studies
Vitamin D3RaisesGrade A
Vitamin D3 raises phosphate.
Meta-analysis or review · Small effect · 8 studies linked
- Schwetz V, Amrein K, et al. (2017)
- Portale AA, Halloran BP, Morris RC Jr. (1989)
- Calcitriol enhances pyrazinamide treatment of murine tuberculosis. (2019)
- Efficacy and safety of burosumab compared with conventional therapy in patients with X-linked hypophosphatemia: A systematic review. (2024)
- Phosphate concentration is exceptionally high in seminal fluid and is linked with semen quality but not influenced by vitamin D and calcium supplementation. (2025)
- Daily versus fortnightly oral vitamin D (2024)
- +2 more studies
CreatineRaisesGrade B
Creatine raises phosphate.
Human trials · Small effect · 11 studies linked
Serum inorganic phosphate mildly elevated during creatine loading phase due to PCr-phosphate cycling and renal phosphate handling. Returns to baseline with maintenance dosing (3–5g/day). Clinically insignificant in healthy individuals. Corpus coverage: 467 studies (high).
- The Effect of Creatine Supplementation on Muscle Function in Childhood Myositis: A Randomized, Double-blind, Placebo-controlled Feasibility Study. (2021)
- Lactate infusion increases brain energy content during euglycemia but not hypoglycemia in healthy men. (2019)
- Effects of branched-chain amino acids supplementation on both plasma amino acids concentration and muscle energetics changes resulting from muscle damage: A randomized placebo controlled trial. (2016)
- Impact of salbutamol on muscle metabolism assessed by ³¹P NMR spectroscopy. (2015)
- Effect of creatine monohydrate in improving cellular energetics and muscle strength in ambulatory Duchenne muscular dystrophy patients: a randomized, placebo-controlled 31P MRS study. (2010)
- Intratumoral Concentrations and Effects of Orally Administered Micellar Curcuminoids in Glioblastoma Patients. (2016)
- +5 more studies
L-carnitineLowersGrade B
L-carnitine lowers phosphate.
Meta-analysis or review · 4 studies linked
134 studies; co-reported in CKD/dialysis. No direct mechanism for phosphate modulation by L-carnitine.
- L-Carnitine and Acetyl-L-Carnitine in Drug Poisonings: A Systematic Review of Clinical and Experimental Evidence. (2026)
- Effects of L-Carnitine on Mineral Metabolism in the Multicentre, Randomized, Double Blind, Placebo-Controlled CARNIDIAL Trial. (2018)
- Effect of L-carnitine on myocardial metabolism: results of a balanced, placebo-controlled, double-blind study in patients undergoing open heart surgery. (1998)
- Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. (1995)
BerberineLowersGrade B
Berberine lowers phosphate.
Human trials · 1 study linked
NAD+RaisesGrade B
NAD+ raises phosphate.
Human trials · 1 study linked
10 corpus studies — highest electrolyte coverage. SIRT1-FGF23 axis in renal phosphate handling provides mechanistic basis. Priority extraction target.
Studied, no change6
Studies looked and found no meaningful change. That is a result, not missing data.
MagnesiumNo changeGrade A
Studies of Magnesium found no change in phosphate.
Meta-analysis or review · 2 studies linked
Phosphate not a primary Mg target. CKD-MBD context: Mg may modestly reduce phosphate via FGF23 pathway but evidence is thin.
Vitamin CNo changeGrade A
Studies of Vitamin C found no change in phosphate.
Meta-analysis or review · 1 study linked
262 studies. No extraction.
AshwagandhaNo changeGrade B
Studies of Ashwagandha found no change in phosphate.
Human trials · 1 study linked
Ubiquinol (CoQ10)No changeGrade C
Studies of Ubiquinol (CoQ10) found no change in phosphate.
ZincNo changeGrade C
Studies of Zinc found no change in phosphate.
Human trials · 0 studies linked
This result is graded, but no study is linked to it yet. Treat it as unconfirmed.
Large corpus count (198) reflects phosphate monitoring in CKD/dialysis studies. Zinc does not directly regulate phosphate homeostasis.
Omega-3No changeGrade D
Studies of Omega-3 found no change in phosphate.
Small effect · 0 studies linked
This result is graded, but no study is linked to it yet. Treat it as unconfirmed.
Not studied15
No usable human study has measured Phosphate with these. A gap is not a negative result: nobody has looked.
CollagenFinnish saunaHIITL-theanineLion's maneMelatoninMilk thistleNACPQQRed yeast riceResveratrolTaurineVitamin EVitamin K2Zone 2 cardio