01Markers · Minerals
Calcium
The most abundant mineral in the body, stored mainly in bone. The blood test measures the small amount circulating, which the body holds within tight limits.
- Measured in
- Blood (serum)
- Units
- mg/dL, mmol/L
- Also called
- Ca, serum calcium, ionized calcium
- Resveratrol
- Vitamin D3
- Collagen
- L-carnitine
- Melatonin
- Milk thistle
- Taurine
- Finnish sauna
- Iron
- Vitamin C
- Vitamin K2
- Zinc
- Omega-3
- NAD+
- Creatine
- Ashwagandha
- Magnesium
- HIIT
- Berberine
- L-theanine
- Lion's mane
- NAC
- PQQ
- Red yeast rice
- Ubiquinol (CoQ10)
- Vitamin E
- Zone 2 cardio
AWhat moves Calcium
18 of 27 studied
Moves it8
Human studies found a change. The grade reflects the studies behind it, from A (strongest) to D.
ResveratrolLowersGrade A
Resveratrol lowers calcium.
Meta-analysis or review · 3 studies linked
152 corpus studies (many in bone metabolism context). Serum calcium not a primary RCT endpoint for resveratrol.
- Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: effects on lipid profiles, inflammation markers, and quality of life. (2013)
- CSF from amyotrophic lateral sclerosis patients produces glutamate independent death of rat motor brain cortical neurons: protection by resveratrol but not riluzole. (2011)
- Effects of resveratrol supplementation on bone biomarkers: a systematic review and meta-analysis. (2019)
Vitamin D3RaisesGrade A
Vitamin D3 raises calcium.
Meta-analysis or review · 2 studies linked
- Bolland (2015) · not matched to a paper yet
- Schwetz V, Amrein K, et al. (2017)
CollagenRaisesGrade B
Collagen raises calcium.
Human trials · 5 studies linked
- Efficacy and Possible Mechanisms of Astragali Radix and its Ingredients in Animal Models of Osteoporosis: A Preclinical Review and Metaanalysis. (2024)
- Can supplements with prebiotic fibres positively influence bone health in type 2 diabetes? Insights from a randomised controlled crossover trial. (2025)
- Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes. (2015)
- Collagen Peptides from Crucian Skin Improve Calcium Bioavailability and Structural Characterization by HPLC-ESI-MS/MS. (2017)
- Consequences of a plant-based diet with low dairy consumption on intake of bone-relevant nutrients. (2009)
L-carnitineImprovesGrade B
L-carnitine improves calcium.
Human trials · 3 studies linked
65 studies; commonly co-reported in CKD/dialysis trials as safety parameter. No direct carnitine-calcium interaction.
- Effect of levocarnitine plus iron sucrose on nutritional status and life cycle in uremic patients with renal anemia. (2025)
- The effects of adjunctive treatment with L-carnitine on monitoring laboratory variables in ICU patients: a double-blinded randomized controlled clinical trial. (2023)
- Effects of L-Carnitine on Mineral Metabolism in the Multicentre, Randomized, Double Blind, Placebo-Controlled CARNIDIAL Trial. (2018)
MelatoninImprovesGrade B
Melatonin improves calcium.
Human trials · 1 study linked
236 studies reference calcium. Bone metabolism data suggests possible osteoprotective effects but no serum calcium MA.
Milk thistleChangesGrade C
Milk thistle changes calcium.
Human trials · 1 study linked
19 studies; no targeted calcium endpoint. Safety monitoring only.
TaurineRaisesGrade C
Taurine raises calcium.
Lab or animal studies · 1 study linked
212 corpus studies — highest coverage. Reflects taurine's calcium homeostasis mechanism (mech_calcium_homeostasis), not a circulating biomarker effect.
Finnish saunaLowersGrade D
Finnish sauna lowers calcium.
0 studies linked
This result is graded, but no study is linked to it yet. Treat it as unconfirmed.
Studied, no change8
Studies looked and found no meaningful change. That is a result, not missing data.
IronNo changeGrade A
Studies of Iron found no change in calcium.
Meta-analysis or review · 5 studies linked
Iron supplementation does not directly affect serum calcium. Competitive absorption inhibition (calcium reduces iron absorption) is a drug interaction, not a calcium biomarker effect.
- Long-Term and Transient Calcium Channel Blockers; A Systematic Review of Their Role in the Management of Cardiomyopathy in Transfusion-Dependent Thalassemia. (2025)
- Effect Of Levocarnitine Plus Iron Sucrose On Nutritional Status And Life Cycle In Uremic Patients With Renal Anemia (2025)
- Mineral supplementation for very preterm infants fed fortified human milk. (2024)
- Ferric citrate for the treatment of hyperphosphatemia and iron deficiency anaemia in patients with NDD-CKD: a systematic review and meta-analysis. (2024)
- Skeletal Lipocalin-2 Is Associated with Iron-Related Oxidative Stress in ob/ob Mice with Sarcopenia. (2021)
Vitamin CNo changeGrade A
Studies of Vitamin C found no change in calcium.
Meta-analysis or review · 3 studies linked
189 studies. Many in bone/mineral or oxalate context. No direct vitamin C → serum calcium effect extracted.
- Effect of different periods of chronic heat stress with or without vitamin C supplementation on bone and selected serum parameters of broiler chickens. (2018)
- Implications of high-dose vitamin D (2025)
- Effect of Ascorbic Acid on Mineral and Bone Disorders in Hemodialysis Patients: a Systematic Review and Meta-Analysis. (2018)
Vitamin K2No changeGrade B
Studies of Vitamin K2 found no change in calcium.
9 studies linked
77 studies reference calcium — most extensively studied electrolyte in K2 context. K2 redirects calcium deposition (from arteries to bone) via MGP/osteocalcin mechanisms but does NOT raise serum calcium levels. No hypercalcemia signal in any K2 trial.
- Efficacy of Recombinant Human Parathyroid Hormone 1-34 and Vitamin K2 Combination Therapy in Postmenopausal Osteoporosis. (2025)
- Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study. (2020)
- Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study. (2020)
- Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine. (2004)
- Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. (2002)
- Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis. (2000)
- +3 more studies
ZincNo changeGrade B
Studies of Zinc found no change in calcium.
Human trials · 3 studies linked
Large corpus count (505) reflects calcium measured as part of mineral panels in nutrition and CKD studies. Zinc supplementation at therapeutic doses does not consistently alter serum calcium.
- Effect of a Short Messaging Service (SMS) intervention delivered to caregivers on energy, nutrients, and food groups intake in infant participants of the WIC program. (2022)
- Micronutrient Adequacy and Dietary Diversity Exert Positive and Distinct Effects on Linear Growth in Urban Zambian Infants. (2016)
- Co-supplementation of Zinc and Calcium Suppresses Bio-absorption of Lead in Sprague Dawley Rats. (2023)
Omega-3No changeGrade B
Studies of Omega-3 found no change in calcium.
Human trials · Negligible effect · 2 studies linked
NAD+No changeGrade B
Studies of NAD+ found no change in calcium.
Human trials · 1 study linked
7 corpus studies — priority extraction target. NAADP (NAD+ metabolite) is a calcium signaling second messenger; calcium homeostasis effects are mechanistically plausible.
CreatineNo changeGrade B
Studies of Creatine found no change in calcium.
0 studies linked
This result is graded, but no study is linked to it yet. Treat it as unconfirmed.
No calcium-relevant mechanism; serum calcium unaffected in safety monitoring data
AshwagandhaNo changeGrade C
Studies of Ashwagandha found no change in calcium.
Human trials · 2 studies linked
- Safety and clinical effectiveness of Withania Somnifera (Linn.) Dunal root in human ailments. (2020)
- The effects of dietary 1, 25-dihydroxycholecalciferol and hydroalcoholic extract of Withania somnifera root on bone mineralisation, strength and histological characteristics in broiler chickens. (2013)
Mixed results2
Studies disagree, or the direction depends on who was studied.
MagnesiumMixed resultsGrade A
Studies of Magnesium and calcium disagree.
Meta-analysis or review · 8 studies linked
In severe hypomagnesemia, Mg correction restores PTH secretion and corrects secondary hypocalcemia. In normomagnesemic individuals, calcium unaffected.
- The Impact of Lipid Apheresis on Changes of Plasma Ions: A Systematic Review and Meta-Analysis. (2026)
- Can supplements with prebiotic fibres positively influence bone health in type 2 diabetes? Insights from a randomised controlled crossover trial. (2025)
- Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial. (2019)
- Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress. (2018)
- The Effects of Magnesium Supplementation on Serum Magnesium and Calcium Concentration in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (2022)
- Effect of Magnesium Supplementation on Chronic Kidney Disease-Mineral and Bone Disorder in Hemodialysis Patients: A Meta-Analysis of Randomized Controlled Trials (2021)
- +2 more studies
HIITMixed resultsGrade B
Studies of HIIT and calcium disagree.
Human trials · 1 study linked
Not studied9
No usable human study has measured Calcium with these. A gap is not a negative result: nobody has looked.
BerberineL-theanineLion's maneNACPQQRed yeast riceUbiquinol (CoQ10)Vitamin EZone 2 cardio