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01Markers · Thyroid

TSH

Thyroid-stimulating hormone

A hormone from the pituitary gland that tells the thyroid to make thyroid hormones. It rises when thyroid hormone runs low and falls when it runs high.

Measured in
Blood (serum)
Units
mIU/L
Also called
thyrotropin
  1. Ashwagandha
  2. L-carnitine
  3. HIIT
  4. Iron
  5. Zinc
  6. Vitamin D3
  7. Berberine
  8. Magnesium
  9. NAC
  10. Melatonin
  11. Resveratrol
  12. Collagen
  13. Creatine
  14. Finnish sauna
  15. L-theanine
  16. Lion's mane
  17. Milk thistle
  18. NAD+
  19. Omega-3
  20. PQQ
  21. Red yeast rice
  22. Taurine
  23. Ubiquinol (CoQ10)
  24. Vitamin C
  25. Vitamin E
  26. Vitamin K2
  27. Zone 2 cardio
TSH across the 27 supplements and practices researched so far · best evidence first

AWhat moves TSH

11 of 27 studied

In human studies, 3 of the 27 supplements and practices researched so far lowered TSH and 1 raised it. 6 showed no change and 1 had mixed results. 16 were never studied for it.
  • Supported 4
  • No effect 6
  • Conflicting 1
  • Not studied 16
See TSH on the evidence map →Check claims about TSH →

Moves it4

Human studies found a change. The grade reflects the studies behind it, from A (strongest) to D.

AshwagandhaLowersGrade B

Ashwagandha lowers TSH.

Human trials · 2 studies linked

Studied in: Subclinical hypothyroid patients, Caution in euthyroid individuals, Extreme caution if hyperthyroid tendency

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L-carnitineRaisesGrade B

L-carnitine raises TSH.

Human trials · Modest effect · 2 studies linked

Studied in: Hyperthyroid, Euthyroid on replacement

8 studies in corpus. L-carnitine is a peripheral thyroid hormone antagonist (mech_011); TSH may rise compensatorily when peripheral thyroid action is blunted. Most data from hyperthyroid treatment context (Benvenga et al.). Euthyroid individuals unlikely to see clinically significant TSH change at standard doses.

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HIITLowersGrade B

HIIT lowers TSH.

Human trials · 1 study linked

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IronLowersGrade C

Iron lowers TSH.

Small effect · 1 study linked

Studied in: Iron deficient, Developing world

TSH may be mildly elevated in iron deficiency due to impaired thyroid peroxidase activity. Iron repletion normalises TSH toward normal range. Effect most evident in populations with concurrent iodine sufficiency.

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Studied, no change6

Studies looked and found no meaningful change. That is a result, not missing data.

ZincNo changeGrade B

Studies of Zinc found no change in TSH.

Human trials · 3 studies linked

Studied in: Hypothyroid, Autoimmune thyroiditis, Overweight, Adults

Zinc monotherapy does not reliably normalize TSH. Zinc-selenium combination may have additive thyroid benefits (zavros_2023_1). One pediatric RCT (ramachandran_2023) showed reduction in thyroid autoantibodies in autoimmune thyroiditis, suggesting immune-modulating role distinct from TSH effect.

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Vitamin D3No changeGrade B

Studies of Vitamin D3 found no change in TSH.

Human trials · 2 studies linked

Studied in: Hashimotos thyroiditis, Autoimmune

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BerberineNo changeGrade B

Studies of Berberine found no change in TSH.

Human trials · 1 study linked

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MagnesiumNo changeGrade B

Studies of Magnesium found no change in TSH.

Human trials · 1 study linked

Studied in: Adults

Theoretical Mg-thyroid link proposed but no human RCT evidence for TSH modulation by Mg supplementation.

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NACNo changeGrade B

Studies of NAC found no change in TSH.

Human trials · Negligible effect · 1 study linked

Studied in: Adult

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MelatoninNo changeGrade C

Studies of Melatonin found no change in TSH.

Negligible effect · 1 study linked

Studied in: Adults, Euthyroid, Hypothyroid

Preclinical evidence for MT receptor expression on thyroid tissue; human RCT data insufficient to detect meaningful TSH change in euthyroid subjects; no robust MA-level data; grade C reflects mechanistic plausibility without human clinical confirmation

  • study mel luboshitzky2002 · not matched to a paper yet
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Mixed results1

Studies disagree, or the direction depends on who was studied.

ResveratrolMixed resultsGrade B

Studies of Resveratrol and TSH disagree.

Human trials · 1 study linked

Studied in: Adults

5 corpus studies. No dedicated thyroid function RCT. Gap. See oq_rsv_007.

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Not studied16

No usable human study has measured TSH with these. A gap is not a negative result: nobody has looked.

CollagenCreatineFinnish saunaL-theanineLion's maneMilk thistleNAD+Omega-3PQQRed yeast riceTaurineUbiquinol (CoQ10)Vitamin CVitamin EVitamin K2Zone 2 cardio

Commission research on a gap →

Why trials measure it. The standard first test of thyroid function, which trials report as both an effect and a safety measure.

About this marker: TSH (Thyroid-stimulating hormone) Test (MedlinePlus, U.S. National Library of Medicine).

Evidence states come from published human studies found in PubMed and OpenAlex and read by a model pipeline. "Not studied" means no usable human study was found for this marker, which is a gap, not a negative result. Every result links its studies so you can check it.

Research summary for education. Not medical advice.