Platelets

Meta-analysis or review · 3 studies linked

• Effect of HIIT on hemostasis and vascular stiffness: a systematic review and meta-analysis of randomized controlled trials. (2025)
• Acute hematological, metabolic, and inflammatory responses to simulated-6000 ft masked versus unmasked high-intensity interval training in youth soccer players: a randomized crossover pilot study. (2025)
• High-Intensity Interval Training Reduces Liver Enzyme Levels and Improves MASLD-Related Biomarkers in Overweight/Obese Girls. (2025)

Human trials · 7 studies linked

Studied in: Adults

148 corpus studies (primarily platelet aggregation/function studies, not count). Platelet count itself not a primary endpoint. Platelet function (aggregation) is decreased via COX inhibition (mech_rsv_005).

• Effects of resveratrol on inflammatory cytokines in COVID-19 patients: a randomized, double-blinded, placebo-controlled clinical trial. (2025)
• Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease (2012)
• Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. (2011)
• Resveratrol, at Concentrations Attainable with Moderate Wine Consumption, Stimulates Human Platelet Nitric Oxide Production3 (2008)
• Effect of resveratrol on platelet aggregation in vivo and in vitro. (2002)
• Synthesis and Biological Evaluation of Resveratrol Methoxy Derivatives. (2023)
• +1 more studies

Human trials · 5 studies linked

42 studies mention platelets but dedicated effect data not extracted. No known direct mechanism.

• The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trial. (2024)
• A randomized clinical trial to evaluate the efficacy of L-carnitine L-tartrate to modulate the effects of SARS-CoV-2 infection. (2023)
• L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-α 2b plus ribavirin. (2011)
• A Pilot Study on the Effects of l-Carnitine and Trimethylamine-N-Oxide on Platelet Mitochondrial DNA Methylation and CVD Biomarkers in Aged Women. (2020)
• L-carnitine inhibits a subset of platelet activation responses in chronic uraemia. (2007)

Human trials · 3 studies linked

Studied in: General

48 corpus studies. High count suggests platelets measured as routine co-variate, not primary endpoint.

• Taurine ameliorates blood pressure and vascular function in patients with type 2 diabetes: Randomized, double-blind, placebo-controlled trial. (2025)
• Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure. (2017)
• No effect of taurine on platelet aggregation in men with a predisposition to type 2 diabetes mellitus. (2005)

Human trials · Small effect · 0 studies linked

This result is graded, but no study is linked to it yet. Treat it as unconfirmed.

Studied in: General ida, Pediatric

IDA commonly causes secondary thrombocytosis; platelet normalisation after iron treatment is well-described but rarely clinically significant

Small effect · 0 studies linked

This result is graded, but no study is linked to it yet. Treat it as unconfirmed.

Studied in: Adults, Cancer patients, Chemotherapy

Thrombocytopenia attenuation in chemotherapy patients; grade C — limited trials, heterogeneous populations; mechanistic basis involves platelet precursor protection from oxidative damage

Lab or animal studies · 0 studies linked

This result is graded, but no study is linked to it yet. Treat it as unconfirmed.

Human trials · 1 study linked

Studied in: Healthy, Overweight, Age 40 60

Grade corrected from A to B: single source RCT only.

• Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. (2019)

Human trials · Negligible effect · 5 studies linked

• Investigating the Effect of High-Dose Vitamin D3 Administration on Inflammatory Biomarkers in Patients with Moderate to Severe Traumatic Brain Injury: A Randomized Clinical Trial. (2024)
• Vitamin D Supplementation Modulates Platelet-Mediated Inflammation in Subjects With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial. (2022)
• Efficacy of low-fat milk and yogurt fortified with vitamin D (2022)
• [Clinical Study on Calcitriol Combined with Sirolimus in the Treatment of Chronic Primary Immune Thrombocytopenia Patients]. (2021)
• Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial. (2019)

Human trials · 5 studies linked

Studied in: Adult

VE inhibits platelet aggregation (function) but does not affect platelet count. Platelet count stable across VE supplementation trials.

• Measures of cellular oxidative damage following vitamin E supplementation in young patients with transfusion-dependent thalassemia: a double-blind randomized controlled trial. (2025)
• Effects of supplemental Bacillus subtilis, injectable vitamin E plus selenium, or both on health parameters during the transition period in dairy cows in a tropical environment. (2021)
• Increasing Selenium and Vitamin E in Dairy Cow Milk Improves the Quality of the Milk as Food for Children. (2019)
• Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial. (2017)
• Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. (2015)

Human trials · Negligible effect · 4 studies linked

Studied in: Adult

• N-acetylcysteine reduces incidence and duration of linezolid-associated thrombocytopenia in critically ill patients: A randomized controlled trial. (2026)
• Integration of multiomics data shows down regulation of mismatch repair and tubulin pathways in triple-negative chemotherapy-resistant breast tumors. (2023)
• Evaluating the Effect of Intracoronary N-Acetylcysteine on Platelet Activation Markers After Primary Percutaneous Coronary Intervention in Patients With ST-Elevation Myocardial Infarction. (2016)
• PubMed 28397969

Human trials · 3 studies linked

Studied in: Sepsis, General population

67 studies. Müller 2025 (PMID:40927646) post hoc of LOVIT trial: vitamin C did not affect platelet counts in sepsis patients. Ex vivo data (Mohammed 2017) shows no effect at physiological concentrations.

• Vitamin C Does Not Affect Platelet Counts in Patients With Sepsis: A Post hoc Analysis of the Lessening Organ Dysfunction With Vitamin C Randomized Trial. (2025)
• Anti-Inflammatory, Antithrombotic and Antioxidant Efficacy and Synergy of a High-Dose Vitamin C Supplement Enriched with a Low Dose of Bioflavonoids; In Vitro Assessment and In Vivo Evaluation Through (2025)
• Mohammed BM,Fisher BJ,Kraskauskas D,Farkas D,Brophy DF,Fowler AA 3rd,Natarajan R (2017)

Human trials · 2 studies linked

Studied in: Adults

Mg has mild antiplatelet aggregation effects (Ca2+ antagonism) but does not affect platelet count.

• Effects of Nifedipine and Labetalol Combined with Magnesium Sulfate on Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients with Pregnancy-Induced Hypertensi (2022)
• The effect of magnesium sulfate on post off-pump coronary artery bypass grafting bleeding. (2016)

1 study linked

Studied in: Healthy adults

Platelet count and function unaffected; no coagulation pathway interaction identified

• Protection of ischemic myocardium by exogenous phosphocreatine (neoton): pharmacokinetics of phosphocreatine, reduction of infarct size, stabilization of sarcolemma of ischemic cardiomyocytes, and ant (1986)

Human trials · 2 studies linked

Studied in: Burn patients, Antiphospholipid syndrome

• Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial. (2017)
• Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial (2024)

Human trials · 1 study linked

Studied in: Healthy adults

• Safety and clinical effectiveness of Withania Somnifera (Linn.) Dunal root in human ailments. (2020)

Human trials · 1 study linked

• Phase I clinical trial of carboplatin and 41.8 degrees C whole-body hyperthermia in cancer patients. (1993)

Human trials · 1 study linked

Studied in: Adults

Zinc has mild anti-aggregatory properties (thromboxane A2 modulation) but platelet count is not a reliable endpoint for zinc supplementation effects. No MA evidence for significant platelet count change.

• Cotton gauze fabricated with hydro-stable Zn-MOF enables hemostasis acceleration, antibacterial activity, and wound regeneration. (2025)

Meta-analysis or review · Small effect · 8 studies linked

Studied in: Adult, Cardiovascular

Platelet aggregation/reactivity reduced more consistently than platelet count. Clinically relevant at high doses (>3 g/d). 162 studies in corpus.

• The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. (2024)
• No effect of omega-3 polyunsaturated fatty acid supplementation on inflammatory markers in familial hypercholesterolemia: a randomized crossover trial. (2023)
• Influence of different supplementation on platelet aggregation in patients with rheumatoid arthritis (2019)
• Efficacy of a long-term home parenteral nutrition regimen containing fish oil-derived n-3 polyunsaturated fatty acids: a single-centre, randomized, double blind study. (2018)
• Effects of sarpogrelate, eicosapentaenoic acid and pitavastatin on arterioslcerosis obliterans-related biomarkers in patients with type 2 diabetes (SAREPITASO study). (2018)
• Effects of omega-3 polyunsaturated fatty acids and aspirin, alone and combined, on canine platelet function. (2018)
• +2 more studies