01Markers · Inflammation

Fibrinogen

A protein made by the liver that forms the fibrin threads of a blood clot. Its level also rises with inflammation.

Measured in: Blood (plasma)
Units: mg/dL, g/L
Also called: factor I

HIIT
L-carnitine
Berberine
Omega-3
Vitamin C
Zinc
NAC
Resveratrol
Ashwagandha
Collagen
Creatine
Finnish sauna
Iron
L-theanine
Lion's mane
Magnesium
Melatonin
Milk thistle
NAD+
PQQ
Red yeast rice
Taurine
Ubiquinol (CoQ10)
Vitamin D3
Vitamin E
Vitamin K2
Zone 2 cardio

Fibrinogen across the 27 supplements and practices researched so far · best evidence first

AWhat moves Fibrinogen

8 of 27 studied

In human studies, 7 of the 27 supplements and practices researched so far lowered fibrinogen. 1 showed no change. 19 were never studied for it.

Supported 7
No effect 1
Conflicting 0
Not studied 19

See Fibrinogen on the evidence map →Check claims about Fibrinogen →

Moves it7

Human studies found a change. The grade reflects the studies behind it, from A (strongest) to D.

HIITLowersGrade A

HIIT lowers fibrinogen.

Meta-analysis or review · 2 studies linked

Studied in: Cardiac patients, Overweight obese

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L-carnitineLowersGrade B

L-carnitine lowers fibrinogen.

Human trials · 2 studies linked

6 studies in corpus; insufficient dedicated data. Fibrinogen is an acute phase reactant and coagulation factor; L-carnitine's anti-inflammatory mechanism could theoretically reduce it but evidence is absent.

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BerberineLowersGrade B

Berberine lowers fibrinogen.

Human trials · 1 study linked

Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice. (2011)

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Omega-3LowersGrade B

Omega-3 lowers fibrinogen.

Small effect · 1 study linked

Studied in: Cardiovascular risk, General adult

Evidence for a protective (synergistic?) effect of B-vitamins and omega-3 fatty acids on cardiovascular diseases. (2004)

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Vitamin CLowersGrade C

Vitamin C lowers fibrinogen.

1 study linked

Studied in: Adults, Cardiovascular risk, Elevated fibrinogen

Mohammed BM,Fisher BJ,Kraskauskas D,Farkas D,Brophy DF,Fowler AA 3rd,Natarajan R (2017)

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ZincLowersGrade C

Zinc lowers fibrinogen.

Human trials · 1 study linked

Studied in: Metabolic syndrome, T2D, Adults

Fibrinogen as acute-phase reactant may decrease with zinc's anti-inflammatory effects. Directionally consistent with CRP reduction but rarely measured as primary endpoint in zinc supplementation trials.

Zinc supplementation is associated with a reduction in serum markers of inflammation and oxidative stress in adults: A systematic review and meta-analysis of randomized controlled trials. (2021)

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NACLowersGrade C

NAC lowers fibrinogen.

Human trials · Small effect · 0 studies linked

This result is graded, but no study is linked to it yet. Treat it as unconfirmed.

Studied in: Cardiovascular risk, Adult

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Studied, no change1

Studies looked and found no meaningful change. That is a result, not missing data.

ResveratrolNo changeGrade A

Studies of Resveratrol found no change in fibrinogen.

Meta-analysis or review · 2 studies linked

Studied in: Adults

11 corpus studies. No extracted RCT outcome data. Theoretical decrease via anti-inflammatory mechanisms but unconfirmed.

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Not studied19

No usable human study has measured Fibrinogen with these. A gap is not a negative result: nobody has looked.

AshwagandhaCollagenCreatineFinnish saunaIronL-theanineLion's maneMagnesiumMelatoninMilk thistleNAD+PQQRed yeast riceTaurineUbiquinol (CoQ10)Vitamin D3Vitamin EVitamin K2Zone 2 cardio

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